Wei Guo, Ph.D.

Title
Professor
Department
Department of Biology
Institution
University of Pennsylvania
433 S. University Avenue
City, State, Zip
Philadelphia, PA 19104
Phone
215-898-9384
E-mail
guowei[at]sas.upenn.edu
Website
https://www.bio.upenn.edu/people/wei-guo
Research Field
Cell Biology
Award Year
2003

Research

Exocytosis is a basic membrane traffic event mediated by transport, docking, and fusion of secretory vesicles carrying proteins and lipids to the plasma membrane. Through exocytosis, hormones and neurotransmitters can be released. Also through exocytosis, membrane proteins and lipids can be incorporated into specific domains of plasma membrane for cell surface expansion, cell growth, morphogenesis, and cell migration. Our research aims to address two fundamental questions in cell and developmental biology: (1) what is the molecular basis for exocytosis; and (2) how do the secretory machinery functions in concert with cytoskeleton and small-GTP-binding proteins during cell polarization, morphogenesis, and cancer cell metastasis.