Antibiotics are fundamental to modern medicine, essential for treating everything from routine skin infections to strep throat, and for protecting vulnerable patients receiving chemotherapy or being treated in intensive care units. But the proliferation of antibiotic-resistant bacteria—a result of decades of overuse in animal agriculture and human medicine combined with a lack of new drug development and innovation—has placed humanity on the precipice of what public health leaders call a “post-antibiotic” world in which even the most simple surgical procedure could have deadly consequences.
Although antibiotic resistance is not a new problem, its scope now constitutes a major threat to human health. According to the Centers for Disease Control and Prevention, at least 2 million Americans fall sick every year with antibiotic-resistant infections—and 23,000 die.
Medical and public health experts agree that addressing antibiotic resistance requires measures that will ensure both the prudent use of existing drugs and a robust pipeline of new drugs. Pew's antibiotic resistance project supports policies that would:
- Spur the creation of new antibiotics by removing the regulatory, economic, and scientific obstacles that impede antibiotic discovery and development.
- Establish stewardship programs to ensure that antibiotics are prescribed only when necessary in human health care settings.
- End the overuse of antibiotics in food animals.
A new type of antibiotic resistance, first discovered in China at the end of 2015, has been found in bacterial samples from around the world, including the U.S. This resistance is of particular concern because it is caused by a gene, known as mcr-1, that not only makes bacteria resistant to colistin—an antibiotic of last resort in human medicine—but also is readily transferable to... Read More
On Aug. 12, The Pew Charitable Trusts submitted comments to the Centers for Medicare & Medicaid Services on the “conditions of participation” that hospitals and critical access hospitals (CAHs) must meet to receive reimbursement from these programs. Read More
Coordinated and collaborative initiatives such as CARB-X are essential to discovering promising new antibiotics. Read More