Antibiotics are fundamental to modern medicine, essential for treating everything from routine skin infections to strep throat, and for protecting vulnerable patients receiving chemotherapy or being treated in intensive care units. But the proliferation of antibiotic-resistant bacteria—a result of decades of overuse in animal agriculture and human medicine combined with a lack of new drug development and innovation—has placed humanity on the precipice of what public health leaders call a “post-antibiotic” world in which even the most simple surgical procedure could have deadly consequences.
Although antibiotic resistance is not a new problem, its scope now constitutes a major threat to human health. According to the Centers for Disease Control and Prevention, at least 2 million Americans fall sick every year with antibiotic-resistant infections—and 23,000 die.
Medical and public health experts agree that addressing antibiotic resistance requires measures that will ensure both the prudent use of existing drugs and a robust pipeline of new drugs. Pew's antibiotic resistance project supports policies that would:
- Spur the creation of new antibiotics by removing the regulatory, economic, and scientific obstacles that impede antibiotic discovery and development.
- Establish stewardship programs to ensure that antibiotics are prescribed only when necessary in human health care settings.
- End the overuse of antibiotics in food animals.
The Pew Charitable Trusts, the Infectious Diseases Society of America (IDSA), and Trust for America’s Health co-sponsored a July 28 briefing with a panel of antibacterial drug experts and stakeholders to discuss the development of a limited-population antibacterial drug (LPAD) approval pathway. Bipartisan legislation has been approved by the House of Representatives and introduced in the... Read More
As of March 2015, an estimated 36 new antibiotics1 that have the potential to treat serious bacterial infections are in clinical development for the U.S. market. The success rate for drug development is low; at best, only 1 in 5 candidates that enter human testing will be approved for patients.* This snapshot of the antibiotic pipeline will be updated periodically, based on publicly available... Read More
Drug-resistant bacteria, or superbugs, present a serious and worsening threat to human health. According to a Centers for Disease Control and Prevention report, 2 million Americans acquire serious infections caused by antibiotic-resistant bacteria each year, and 23,000 of them die.1 Doctors routinely encounter patients with infections that do not respond to available treatment, and when new... Read More