Peter Baumann, Ph.D.

Title
Professor
Institution
Stowers Institute for Medical Research
Address
1000 East 50th Street
City, State, Zip
Kansas City, MO 64110
Phone
(816) 926-4445
E-mail
peb[at]stowers.org
Website
http://www.stowers.org/faculty/baumann-lab
Research Field
Genetics
Award Year
2003

Research

Our main research goal is to understand how defects in telomere maintenance contribute to cancerogenesis, aging, and various diseases. A better understanding of the dynamic interactions that occur at the telomere will ultimately enable us to identify compounds that modulate telomere length, either to limit the life span of tumor cells or to boost the proliferative potential of desired cell populations. Towards this aim, we employ a variety of techniques in biochemistry, molecular genetics, and cell biology to dissect and elucidate the functions of the protein-nucleic acid complexes at human telomeres. As chromosome end protection and telomere maintenance are common challenges for all organisms with linear chromosomes, several projects in our laboratory rely on the fission yeast Schizosaccharomyces pombe as a model organism. Here we focus on telomerase biogenesis, the regulation of telomere length and the mechanism by which chromosome ends fuse when telomeres fail.