Jens Lykke-Andersen, M.S., Ph.D.

Title
Professor
Department
Division of Biological Sciences
Institution
University of California, San Diego
Address
9500 Gilman Drive # 0322
City, State, Zip
La Jolla, CA 92093-0322
Phone
(858)822-3659
E-mail
jlykkeandersen[at]ucsd.edu
Website
http://www.biology.ucsd.edu/labs/lykkeandersen/
Research Field
Genetics
Award Year
2003

Research

Our laboratory focuses on several aspects of mRNA decay regulation in human cells: 1) Regulation of ARE-mediated mRNA decay: To understand how the TTP-family of ARE-binding proteins activate mRNA decay, we are investigating how they communicate with enzymes involved in mRNA decay. 2) The mechanism of Nonsense-Mediated Decay: We are currently conducting experiments to understand how the EJC communicates with the hUpf proteins and the terminating ribosome. 3) Deadenylation in human mRNA decay: We are currently trying to establish the role of the deadenylases in the ARE- and nonsense-mediated decay pathways. 4) Decapping in human mRNA decay: We identified a human decapping complex that contains at least two proteins, hDcp1 and hDcp2, and we showed that the hDcp2 protein possesses catalytic activity. We affinity purified the decapping complex from a human cell line, and identified three new proteins in the complex. We are currently testing the importance of these novel proteins in mRNA decapping and decay.