Prasad V. Jallepalli, M.D., Ph.D.

Title
Member and Professor
Department
Molecular Biology Program
Institution
Memorial Sloan-Kettering Cancer Center
Address
1275 York Avenue
Box 97 (RRL 1101E)
City, State, Zip
New York, NY 10065
Phone
(212) 639-3252
E-mail
jallepap[at]mskcc.org
Website
http://www.mskcc.org/research/lab/prasad-jallepalli
Research Field
Molecular Biology
Award Year
2003

Research

In the vast majority of solid tumors, genomic instability manifests itself as gross structural and numerical abnormalities affecting chromosomes. This phenotype, termed chromosomal instability (CIN), accounts for the aneuploidy and chromosomal rearrangements found in virtually all cancer cells at the cytogenetic level. Our lab is broadly interested in the mechanisms that control the fidelity of chromosome transmission in human cells, which we suspect may be disrupted in some CIN cancers. To do this, we exploit novel methods that we recently developed to delete genes in cultured human cells. We can thus rapidly generate isogenic cell lines in which a particular gene has been ‘knocked out,’ either constitutively or conditionally.