Deborah T. Hung, M.D., Ph.D.

Title
Assistant Professor
Department
Center for Computational and Integrative Biology
Institution
Massachusetts General Hospital, Harvard University
Address
Richard B. Simches Research Center
185 Cambridge Street, CPZN 7.208
City, State, Zip
Boston, MA 2411
Phone
(617) 643-3117
E-mail
hung[at]molbio.mgh.harvard.edu
Website
http://www.hms.harvard.edu/dms/BBS/fac/hung.php
Research Field
Microbiology
Award Year
2007

Research

The goal of research in the Hung Lab is to understand in vivo mechanisms of bacterial pathogenesis by studying pathogen-host interactions. By merging the fields of chemical genetics and bacterial genetics/genomics, we hope to provide insight into possible new paradigms for addressing infectious diseases. In concert with taking a chemical biological approach to pathogenesis, our lab is interested in developing powerful genomic approaches to systematically and comprehensively identify all bacterial genes required for infection and to facilitate rapid identification of small molecule targeted pathways and interactions. Using small molecules that we identify and develop from high-throughput, forward phenotypic screens and arrayed, knockout libraries of different pathogens, including Vibrio cholerae, Pseudomonas aeruginosa and Mycobacterium tuberculosis, we hope to identify new approaches to disease intervention.