Francis I. Valiyaveetil, Ph.D.

Title
Assistant Professor
Department
Department of Physiology and Pharmacology
Institution
Oregon Health and Science University
Address
3181 SW Sam Jackson Park Road
Mail Code L334
City, State, Zip
Portland, OR 97239
Phone
(503) 418-0946
E-mail
valiyave[at]ohsu.edu
Website
http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/basic-science-departments/physpharm/faculty-staff/valiyaveetil.cfm
Research Field
Biochemistry
Award Year
2007

Research

We study K+ channels, which are integral membrane proteins that catalyze the selective conduction of K+ ions across biological membranes. While a great deal of research has been focused on these channels, fundamental questions regarding the mechanism of ionic selectivity and gating remain. We have developed a unique combination of methods to address these questions. Our methods include the use of chemical synthesis to introduce precise chemical changes in the channels, x-ray crystallography to determine the structural effects and electrophysiology to determine the functional effects of these changes. Using this multidisciplinary approach we are presently investigating the mechanism of K+ selectivity and the process of slow inactivation.