Michael P. Rape, Ph.D.

Title
Professor, Investigator
Department
Molecular Cell Biology
Institution
University of California, Berkeley
Address
300B Li Ka Shing Center for Biomedical Sciences
City, State, Zip
Berkeley, CA 94720
Phone
(510) 289-4413
E-mail
mrape[at]berkeley.edu
Website
https://www.hhmi.org/scientists/michael-rape
Research Field
Cell biology, Biochemistry
Award Year
2007

Research

Ubiquitination is a key regulator of proliferation and differentiation in all eukaryotes. It is carried out by a cascade of three different classes of enzymes, E1, E2, and E3. In humans alone, there are ~40 E2s and more than 600 E3s, making ubiquitination enzymes one of the most abundant and diverse family of enzymes. We know the substrates of only few of these enzymes. My lab is interested in several inter-related projects: discovering ubiquitination enzymes controlling proliferation and differentiation; identifying the pathways regulated by these enzymes during cell cycle control; dissecting the biochemical mechanisms of ubiquitination; and isolating small molecule agonists and antagonists of ubiquitination.