Michelle Krogsgaard, Ph.D.

Title
Assistant Professor
Department
Department of Pathology and Perlmutter Cancer Center
Institution
New York University
Address
522 First Avenue
Smilow Research Center 13th Floor, Room 1311
City, State, Zip
New York, NY 10016
Phone
(212) 263-9266
E-mail
krogsm01[at]nyumc.org
Website
http://www.med.nyu.edu/biosketch/krogsm01/
Research Field
Immunology
Award Year
2007

Research

The goal of the Krogsgaard laboratory is to understand the molecular and cellular events that contribute to T-cell sensitivity to `self’ (cancer) antigens. To accomplish this we employ advanced and highly innovative methods that combine state-of-the-art biophysical methods for characterizing protein-protein interactions e.g. surface plasmon resonance (SPR), X-ray crystallography, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy with imaging methods (single molecule imaging and FRET) and transgenic TCR technologies which makes our research highly interdisciplinary in its nature. Our research is important not only for understanding the activation of signaling pathways important for T cell function but also for the purpose of modulating signaling through the TCR pharmacologically in new and innovative approaches. This is with the purpose of increasing the sensitivity of T-cells in patients with cancer or HIV or decreasing the sensitivity in patients with autoimmune diseases (multiple sclerosis or diabetes).