Markus Stoffel, M.D.

Title
Professor
Department
Institute of Molecular Systems Biology
Institution
Swiss Federal Institute of Technology Zurich
Address
Wolfgang-Pauli-Str. 16
City, Zip
Zürich, 8093
Phone
(41) 44 633 45 60
E-mail
stoffel[at]imsb.biol.ethz.ch
Website
http://www.ccspmd.ethz.ch/people/stmarku
Research Field
Genetics
Award Year
1996

Research

My overall research interest is to determine the fundamental genetic/biochemical mechanisms that regulate glucose and lipid metabolism through the study of transcriptional and translational regulators that control energy homeostasis. The importance of genetic regulation in the maintenance of glucose homeostasis is underscored by the many examples of aberrant signal transduction and transcriptional activation resulting in type 2 diabetes and the development of secondary complications. Our main areas of investigation include 1) Investigation of insulin signaling in liver, fat, hypothalamus and pancreatic ?-cells 2) Identification and characterization of target genes of MODY transcription factors Hnf-1?, Foxa1, Hnf-4? and Pdx-1 3) Islet growth and regeneration 4) MicroRNAs and gene regulation in pancreatic islet cells, liver and intestine 5) HDL metabolism and reverse cholesterol transport 6) Genetics of type 2 diabetes