Charles K. Barlowe, Ph.D.

Title
Professor
Department
Department of Biochemistry
Institution
Dartmouth College
Address
Hinman Box 7200
City, State, Zip
Hanover, NH 3755
Phone
(603) 650-6516
E-mail
Charles.Barlowe[at]dartmouth.edu
Website
http://dms.dartmouth.edu/barlowe/
Research Field
Cell Biology
Award Year
1996

Research

My research program is focused on understanding protein and lipid transport through the early secretory pathway in eukaryotic cells. This is an essential process that initiates the delivery of proteins to intracellular organelles and to the cell surface for secretion. Because of the advantage for genetic analyses, we investigate this process mainly in the yeast Saccharomyces cerevisiae. Our primary interest is elucidating the molecular mechanisms that underlie vesicular transport between the endoplasmic reticulum (ER) and Golgi complex. Transport between these compartments is mediated by membrane vesicles, termed COPII vesicles, that bud from the ER and fuse with and/or form the golgi complex. Our studies combine molecular genetics, proteomics and microscopy with cell free assays that measure COPII-dependent transport.