Athan Kuliopulos, M.D., Ph.D.

Title
Associate Professor of Medicine, Biochemistry & Genetics
Department
Tufts Medical Center
Institution
Tufts University
Address
Department of Medicine
750 Washington Street, Box 7510
City, State, Zip
Boston, MA 2111
Phone
(617) 636-8482
E-mail
athan.kuliopulos[at]tufts.edu
Website
http://sackler.tufts.edu/Faculty-and-Research/Faculty-Research-Pages/Athan-Kuliopulos
Research Field
Molecular Biology
Award Year
1996

Research

Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. The PARs are cleaved by thrombin and other proteases at a specific peptide bond to expose a new N-terminus that binds to the body of the receptor in an unusual intramolecular mode. A major interest of our research group is to study the molecular mechanism of protease activation of the PARs and the subsequent signaling in vascular cells and in cancer. We have established a new technology based on cell-penetrating peptides known as pepducins as a novel approach of activating or inhibiting signaling between selected receptors and G proteins. These cell-penetrating pepducins are powerful tools to evaluate PARs, chemokines, and other receptors as potential therapeutic targets in both in vitro and mouse model systems.