- Department of Cellular and Molecular Biology & Parasitology
- University of Sao Paulo
Av Bandeirantes, 3900
- Ribeirao Preto
- [email protected]
- Research field
- Award year
- Country of origin
- Mentor name
- Stephen M. Beverley, Ph.D.
The H locus present in the Leishmania spp. is a 40 Kb region that codes for genes involved in this pathogen's resistance to drugs and virulence. The projects conducted in our laboratory investigate the amplification phenomenon and the function of the genes contained in this locus in several species of this parasite protozoon. We have characterized the anatomy of this locus in L. braziliensis, and demonstrated that, unlike species of the subgenus Leishmania, the phenomenon of genic amplification is not favored in this species. In addition, we have identified the gene that confers resistance to terbinafine, LmYIP1, and the gene LmHUS1, possibly related to DNA repair processes in the parasite. The objectives of this proposal aim to characterize the genes contained in the H locus of Leishmania spp. More specifically, we will investigate:(i) the involvement of LmYIP1 in the parasite's vesicle traffic;(ii) the structure of the LmHUS1 gene and its involvement in the cell cycle control; and we will characterize(iii) the possible angiostatic action of the parasite's TTRS.
1995 Search Pew Fellows
- Victor Manuel Baizabal Aguirre, D.Sc.
- Rosa Laura Camarena Mejia, Ph.D.
- Sandro Jose de Souza, Ph.D.
- María Beatriz Espinosa, Ph.D.
- Patricia Alejandra Fontan, Ph.D.
- Diego Fraidenraich, Ph.D.
- Roberto A. Gaxiola Ariza, Ph.D.
- Katia Calp Gondim, Ph.D.
- Luiz Ricardo Orsini Tosi, Ph.D.
- Christine M. Pedroarena, M.D.
- Diego Enrique Rincon-Limas, Ph.D.