Saskia B. Neher, Ph.D.

Title
Assistant Professor
Department
Department of Biochemistry and Biophysics
Institution
University of North Carolina at Chapel Hill
Address
120 Mason Farm Rd.
CB 7260
City, State, Zip
Chapel Hill, NC 27599
Phone
(919) 966-9550
E-mail
neher[at]email.unc.edu
Website
http://neherlab.web.unc.edu/
Research Field
Biochemistry
Award Year
2012

Research

Research in my lab focuses on understanding the molecular mechanisms responsible for regulation of lipase activity. We aim to uncover how a transmembrane maturation factor assists in proper folding and ER exit of a group of dimeric mammalian lipases. We also study secreted proteins that regulate lipase activity in response to changes in nutritional state. Our research has biomedical relevance because biochemical deficiencies in lipase activity can cause hypertriglyceridemia, which is associated with increased risk for atherosclerosis. Our approach is interdisciplinary and uses membrane protein biochemistry, enzymology, and structural biology to understand lipase structure-function relationships.