David A. Drummond, Ph.D.

Title
Assistant Professor
Department
Department of Biochemistry and Molecular Biology
Institution
University of Chicago
Address
929 E 57th St
GCIS W234
City, State, Zip
Chicago, IL 60637
Phone
(773) 834-2017
E-mail
dadrummond[at]uchicago.edu
Website
http://drummond.openwetware.org/
Research Field
Biochemistry; Molecular Biology
Award Year
2012

Research

What are the spectrum, frequency and consequences of errors in protein synthesis? How do cells sense and respond to misfolded proteins, particularly in the eukaryotic cytosol? How does stochasticity in protein synthesis alter the composition and stability of the proteome?

What benefits do errors confer? Does error-induced protein misfolding influence the progression of neurodegenerative diseases such as ALS?

We are pursuing mechanistic answers to these questions, taking a biochemical and genetic approach, with an emphasis on developing high-resolution, high-mass-accuracy mass spectrometric techniques for proteome-scale quantitation. From a theoretical standpoint, we are interested in understanding the imprints that natural selection on fidelity and misfolding leave on evolving genes and genomes.