Wolfram Goessling, M.D., Ph.D.

Title
Assistant Professor
Department
Harvard Medical School
Institution
Dana-Farber Cancer Institute, Harvard University
Address
450 Brookline Avenue, 1234C
City, State, Zip
Boston, MA 2115
Phone
(617) 525-4701
E-mail
wolfram_goessling[at]dfci.harvard.edu
Website
http://www.fishing4stemcells.org/index.html
Research Field
Developmental Biology
Award Year
2012

Research

Our laboratory seeks to understand the signals that indicate organ injury and regulate growth and regeneration. The inability to recover from acute injury can lead to organ failure, while a dysregulated regenerative response in the setting of chronic injury may contribute cancer formation. Our specific interests are to define the similarities between development and regeneration of the liver, an important organ for the organism's metabolism and protein synthesis with remarkable regenerative capacities. We investigate zebrafish as the primary model to discover novel regulatory pathways of liver development and evaluate their importance for recovery after toxic and physical injury. Using chemical and genetic modulation, we assess organ formation, repair and carcinogenesis by in vivo imaging, functional genomic methods, and histological analysis to define the principal molecular and cellular mechanisms regulating organ growth and develop novel therapeutic approaches for patients with liver failure and cancer.