Thomas G. Fazzio, Ph.D.

Title
Assistant Professor
Department
Program in Gene Function and Expression
Institution
University of Massachusetts Medical School
Address
364 Plantation Street
LRB 519
City, State, Zip
Worcester, MA 1605
Phone
(508) 856-6014
E-mail
thomas.fazzio[at]umassmed.edu
Website
http://profiles.umassmed.edu/Profiles/display/130158
Research Field
Stem Cell Biology; Genetics
Award Year
2011

Research

We are interested in the roles of chromatin remodeling proteins in regulation of embryonic stem (ES) cell identity. While a number of transcription factors that promote ES cell self-renewal (continued proliferation as stem cells) or differentiation are known, the mechanisms by which they regulate their gene targets are mysterious. Likewise, a number of chromatin regulators are important for ES cell self-renewal or differentiation, but their functions and genomic targets are poorly understood. We are taking genetic, genomic, biochemical and molecular approaches to study the roles of chromatin remodeling proteins in ES cells. These studies should lead to a greater understanding of how chromatin regulators interface with ES cell transcription factors to maintain the transcriptome, which should ultimately pave the way for the development of ES cell-based therapies for degenerative diseases.