Michael S. Kuhns, Ph.D.

Title
Assistant Professor
Department
Department of Immunobiology
Institution
University of Arizona
Address
1656 E Mabel Street
P.O. Box 245221
City, State, Zip
Tucson, AZ 85724
Phone
(520) 626-6461
E-mail
mkuhns[at]email.arizona.edu
Website
http://immunobiology.arizona.edu/faculty/michael-s-kuhns-phd
Research Field
Immunology
Award Year
2011

Research

Effective immunity to pathogens requires that coordinated, multi-cellular responses emerge from a myriad of "conversations" that take place between cells of the innate and adaptive immune compartments. My lab is working to understand the molecular mechanism that mediate the conversations that occur between antigen-presenting cells and T cells that determine if and how a T cell responds to antigen. We are using a variety of classic molecular, cellular, and biochemical techniques, as well as more modern live cell imaging approaches, to probe these processes. We are also developing mouse model systems to determine how individual mechanisms contribute to T cell responses during pathogenic infection or autoimmunity. Altogether, our work is aimed at increasing our basic and practical understanding of T cell activation and regulation.