Ethan Lee, M.D., Ph.D.

Title
Associate Professor
Department
Department of Cell and Developmental Biology
Institution
Vanderbilt University
Address
465 21st Avenue South
U-4213A Learned Lab/MRBIII
City, State, Zip
Nashville, TN 37232-8240
Phone
(615) 322-1307
E-mail
ethan.lee[at]vanderbilt.edu
Website
http://www.vanderbilt.edu/leelab/
Research Field
Molecular Biology
Award Year
2004

Research

The Wnt pathway is an evolutionarily conserved signaling pathway present in all metazoans. During development, Wnt signaling coordinate the formation of tissues, organs, and limbs, and its misregulation leads to a variety of human disease states such Alzheimer's disease and cancer. My laboratory is interested in understanding the basic mechanism by which a Wnt signal is propagated and how this information can be used in regenerative medicine and in the treatment of cancer. A major experimental approach in my laboratory involves the use of Xenopus extracts and purified proteins to biochemically reconstitute Wnt signaling in vitro. Genome-scale screens, cultured mammalian cells, Xenopus embryos, Drosophila genetics (in collaboration with Dr. Laura Lee), and mouse studies are employed to compliment and extend our biochemical findings.