Steven A. Farber, Ph.D.

Title
Principal Investigator/Adjunct Assoc. Professor
Department
Embryology
Institution
Carnegie Institution for Science
Address
3520 San Martin Drive
City, State, Zip
Baltimore, MD 21212
Phone
(410) 246-3072
E-mail
farber[at]ciwemb.edu
Website
http://emb.carnegiescience.edu/labs/farber/index.php
Research Field
Developmental Biology, Biochemistry
Award Year
2002

Research

Work in my laboratory utilizes the zebrafish, to visualize biochemical processes in living embryos by exploiting their accessibility and optical clarity. Specifically, the laboratory has focused on studying lipid modifying and transport processes in the developing embryo. Lipids are known to play a role in a host of physiological processes, most notably inflammation, and in cancer. Despite these findings, little is known about their role in cell signaling events important during embryonic development. A novel aspect of this work is that it examines the regulation of lipid metabolism in vivo by feeding embryos fluorescent lipids and visualizing their uptake, and processing using time-lapse microscopy. We couple these tools with mutagenesis screening to identify genes that regulate lipid metabolism, germ cell migration, intestinal and liver transport, and development of the biliary tract. Identification of these genes has important implications for cancer research and research related to diseases of the liver, intestine and cardiovascular system.