John Rawls, Ph.D.

Title
Associate Professor
Department
Department of Molecular Genetics & Microbiology
Institution
Duke University
Address
213 Research Drive
City, State, Zip
Durham, NC 27710-3580
Phone
(919) 613-7212
E-mail
john.rawls[at]duke.edu
Website
http://rawlslab.duhs.duke.edu/
Research Field
Microbiology
Award Year
2008

Research

We are using the zebrafish (Danio rerio) to investigate the mechanisms underlying host-microbe interactions in the vertebrate gut. We have developed methods for rearing germ-free zebrafish, and used those techniques to identify host responses to the gut microbiota that have been evolutionarily conserved between fish and mammals. To generate simplified experimental platforms, we have also identified individual bacterial members of the gut microbiota that elicit conserved host responses upon colonization of germ-free zebrafish. Current research projects in our lab are focused on the following areas: innate immune responses to the gut microbiota, microbial regulation of host nutrient metabolism, and environmental regulation of adipogenesis.