A. Kimberley McAllister, Ph.D.

Title
Associate Professor
Department
Center for Neuroscience
Institution
University of California, Davis
Address
Medical Neuroscience Building Room 502F
1544 Newton Court
City, State, Zip
Davis, CA 95616
Phone
(530) 752-8114
E-mail
kmcallister[at]ucdavis.edu
Website
http://www.ucdmc.ucdavis.edu/neurology/faculty/mcallister.html
Research Field
Neuroscience
Award Year
2001

Research

Research in McAllister’s laboratory focuses on understanding the cellular and molecular mechanisms of synapse formation, competition, and elimination in the developing visual cortex. The lab studies the formation, persistence, and elimination of individual synapses between dissociated, cultured visual cortical neurons using time-lapse imaging. In addition to studying the cellular and molecular mechanisms of synapse formation and plasticity, her lab is also interested in elucidating the role for immune molecules in early postnatal cortical development. McAllister’s lab is working to identify the role for cytokines and synaptic activity in regulating MHCI expression as well as determining the mechanisms that MHCI uses to negatively regulate cortical connectivity. Since these immune molecules are implicated in several neurodevelopmental disorders, including autism and schizophrenia, MHCI molecules could mediate the effects of the environment on cortical connectivity both during normal development and in neurodevelopmental disorders.