Vanessa Sperandio, Ph.D.

Title
Professor
Department
Department of Microbiology
Institution
University of Texas Southwestern Medical Center
Address
5323 Harry Hines Blvd.
City, State, Zip
Dallas, TX 75390-9048
Country
United States
Phone
214-633-1378
E-mail
vanessa.sperandio[at]utsouthwestern.edu
Website
http://profiles.utsouthwestern.edu/profile/50556/vanessa-sperandio.html
Research Field
Microbiology
Award Year
1997
Country Of Origin
Brazil
Mentor Name
James B. Kaper, Ph.D.

Research

Research in the Sperandio laboratory is directed toward understanding how bacteria recognize the host, and how we can exploit this knowledge to interface with bacterial infections. My laboratory reported that bacterial pathogens, such as enterohemorrhagic E. coli (EHEC), Salmonella typhimurium, Francisella tularensis, typical of the “super bugs,” exploit cell-to-cell signaling between the microbial flora and the host as a means to gage and recognize the host environment. This inter-kingdom signaling is predicated upon hormonal communication, and utilizes the host epinephrine and/or norepinephrine (NE) stress hormones and a bacterial aromatic hormone-like signal names autoinducer-3 (AI-3).