Qing R. Fan, Ph.D.

Title
Assistant Professor of Pharmacology and Pathology
Department
Department of Pharmacology
Institution
Columbia University
Address
Physicians & Surgeons
Room 7-430, 630 W 168th Street
City, State, Zip
New York, NY 10032
Phone
(212) 342-0115
E-mail
qf13[at]columbia.edu
Website
http://sklad.cumc.columbia.edu/pharm/cumc/profile_new.php?id=301
Research Field
Structural Biology
Award Year
2009

Research

Our laboratory studies the molecular mechanisms by which G-protein coupled receptors (GPCRs) transmit signals across biological membranes. GPCRs represent the superfamily of transmembrane receptors that signal through heterotrimeric G-proteins. GPCRs recognize a diverse array of ligands, and are the targets for 50-60% of clinical drugs. We combine x-ray crystallography with various biochemical techniques to study these receptors with two general goals: (1) to determine the specificity of receptor-ligand interactions, and (2) to identify receptor activation mechanisms.