Frank Alber, Ph.D.

Title
Associate Professor
Department
Molecular and Computational Biology
Institution
University of Southern California
Address
1050 Childs Way
RRI 413E
City, State, Zip
Los Angeles, CA 90089
Phone
(213) 740-0778
E-mail
alber[at]usc.edu
Website
http://www.cmb.usc.edu/people/alber/
Research Field
Computational Biology
Award Year
2009

Research

My research is focused on the structural characterization of higher-order chromatin on a genomic scale in order to elucidate the principles that underlie gene regulatory processes, such as gene transcription, replications and cell differentiation. We have developed a computational model for generating a structural description of this highly ordered DNA by merging multiple datasets from a range of experimental methodologies including X-ray crystallography, electron microscopy, genmoe0wide chromatin immunoprecipitation (CHIP) and chromosome conformation capture, to name a few. Our work aims to bridge the gap between genome sequencing, gene regulation and structural biology and provide insights to better understand many human diseases.