Mark D. Fleming, M.D., D.Phil.

Title
Professor and Chairman
Department
Pathology
Institution
Boston Children's Hospital, Harvard University
Address
CHB 3027
300 Longwood Avenue
City, State, Zip
Boston, MA 02115
Phone
(617) 919-2665
E-mail
mark.fleming[at]childrens.harvard.edu
Website
http://www.childrenshospital.org/researchers/mark-fleming
Research Field
Genetics
Award Year
2000

Research

My research is focused on determining how erythroid cells acquire and utilize iron. Researchers in my lab are pursuing two general approaches: 1) Postionally cloning and characterizing the genes underlying several mouse hereditary defects in erythroid iron metabolism. 2) Using targeted mutagenesis in the mouse to study proteins implicated in the pathogenesis in a group of bone marrow disorders known as sideroblastic anemias. In those disorders, erythroid precursors develop pathologic iron deposits in mitochondria, which play a unique role in metabolizing iron and heme. We are seeking to characterize proteins responsible for mitochondrial iron import and utilization.