Barbara L. Golden, Ph.D.

Title
Professor
Department
Biochemistry
Institution
Purdue University
Address
BCHM 319
175 South University Street
City, State, Zip
West Lafayette, IN 47907
Phone
(765) 496-6165
E-mail
barbgolden[at]purdue.edu
Website
https://ag.purdue.edu/biochem/Pages/Profile.aspx?strAlias=rna&intDirDeptID=9
Research Field
Biochemistry
Award Year
2000

Research

The focus of our research is the structure and folding of functional RNAs. Unlike proteins, RNAs have a highly charged backbone, only 4 different monomeric units (compared to the 20 amino acids that make up proteins) and functional groups that are largely sequestered within the major and minor grooves of the double helix. Yet, in the presence of magnesium ion, many RNA molecules have stable, globular, tertiary structures that support biological catalysis. To understand how these molecules fold and function, we are investigating the structure and function of these RNA molecules using biochemistry, molecular biology and X-ray crystallography.