Alan C. Mullen, M.D., Ph.D.

Title
Assistant Professor
Department
Gastrointestinal Unit, Department of Medicine
Institution
Massachusetts General Hospital
Address
55 Fruit Street
Thier 306B
City, State, Zip
Boston, MA 02114
Phone
(617) 699-2065
E-mail
acmullen[at]mgh.harvard.edu
Website
http://mullenlab.mgh.harvard.edu
Research Field
Cell Biology; Molecular Biology
Award Year
2017

Research

Our lab will investigate the role that regulatory RNAs play in chronic liver failure. Chronic liver failure is a devastating disease caused by progressive scarring of the liver tissue from infection and other injury. Aside from liver transplantation, there are limited treatment options available for many causes of chronic liver disease. We have identified more than 400 long noncoding RNAs (lncRNAs) found exclusively in the hepatic stellate cells, which produce this fibrotic scarring. Now, using a suite of state-of-the-art techniques in genetics, genomics, and physiology, we will determine which lncRNAs regulate the production of scar tissue in humans and mice, and whether inhibiting their action can prevent fibrosis—work that could lead to a novel treatment to prevent liver failure.