Shing Y. Chiu, Ph.D.

Title
Professor
Department
Department of Physiology
Institution
University of Wisconsin-Madison
Address
285 Medical Science Building
1300 University Avenue
City, State, Zip
Madison, WI 53706
Phone
(608) 262-6994
E-mail
chiu[at]physiology.wisc.edu
Website
http://www.physiology.wisc.edu/faculty/chiu.html
Research Field
Neuroscience
Award Year
1987

Research

Potassium channels are crucial modulators of excitability in normal and pathological nerves. In the mammals, multiple K channel gene families encode different gene products exhibiting diversity in kinetics, cellular localizations, and responsiveness to second messengers. The goal of this laboratory is to elucidate the in vivo functions of K channels using a combination of electrophysiology (S.Y. Chiu) and transgenics/gene knockout techniques (Albee Messing). Our current focus is on Shaker Channels (Kv1.1, Kv1.2, Kv1.5) and auxiliary K channel subunits (Kvb1/Kvb2) . Viable global knockout mice of these channel genes have been produced and are now under physiological and molecular analysis. Currently, two broad questions are being addressed. First, what is the functional impact of deleting these K channels in normal and demyelinated nerves particularly at axonal branch points? Second, do the Kvb subunits assist in delivering the K channel a subunits to the final destination?”

Scholar Keywords