Edward Chouchani, Ph.D.

Title
Assistant Professor
Department
Cancer Biology and Cell Biology
Institution
Dana-Farber Cancer Institute, Harvard Medical School
Address
360 Longwood Ave.
City, state, ZIP
Boston, MA 02215
Phone
617-632-3281
Email
[email protected]
Website
https://chouchanilab.dana-farber.org
Research field
Chemical Biology
Award year
2021

Research

The Chouchani lab will study how the chemically reactive byproducts of metabolism regulate the activity of proteins involved in inflammation and obesity. Energy-generating metabolic reactions produce highly reactive chemical byproducts. Although these reactive chemicals, left unchecked, can damage cell components, my lab has discovered that they also serve to regulate the activity of some cellular proteins. In my laboratory, we developed a method that allowed us to identify more than 9,000 proteins in 10 different mouse tissues that contain sites that can be modified by these reactive chemicals. Now, combining these resources with cutting-edge techniques in chemical biology, physiology, pharmacology, and protein chemistry, we will identify compounds that similarly target the vulnerable sites in two major classes of protein: those that generate inflammatory signaling molecules, and a second that controls energy expenditure and plays a role in obesity and diabetes. After maximizing the potency and specificity of these compounds, we will test how effective they are at inhibiting the activity of these target proteins in mice. This work could lead to promising new drugs for treating metabolic and inflammatory disorders.

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