Trever Bivona, M.D., Ph.D.

Title
Assistant Professor
Department
Department of Medicine, Hematology Oncology
Institution
University of California, San Francisco
Address
600 16th Street
Room N212D
City, State, Zip
San Francisco, CA 94158
Phone
(415) 476-9907
E-mail
tbivona[at]medicine.ucsf.edu
Website
http://bivonalab.surgery.ucsf.edu/
Research Field
Cell Biology; Genetics
Award Year
2015

Research

The goal of my research is to explore how tumors with mutations in a specific cell communication process, known as the Ras signaling pathway, become resistant to drugs. Inappropriate activation of the Ras signaling pathway drives the development of a variety of human tumors, including cancers of the lung, pancreas, and colon. Unfortunately, drugs that block Ras function have been clinically ineffective and are often undermined by drug resistance. I discovered that eliminating a specific protein from cancer cells enhances the effectiveness of drugs that inhibit the Ras signaling pathway. Using genetics and tools from cellular and molecular biology, I will identify compounds that can block Ras function in tumor cells from patients. This work could reveal novel strategies for avoiding drug resistance and prolonging patient survival.