Vinicius de Andrade-Oliveira, Ph.D.

Title
Postdoctoral Fellow
Department
Mucosal Immunology Section; Laboratory of Parasitic Diseases
Institution
The National Institute of Allergy and Infectious Disease, NIH
Address
4 Center Drive
Room 243
City, State, Zip
Bethesda, MD 20892
Phone
301-451-8686
E-mail
andradevinicius1[at]gmail.com
Website
http://www.niaid.nih.gov/LabsAndResources/labs/aboutlabs/lpd/mucosalImmunology/Pages/belkaid.aspx
Research Field
Immunology
Award Year
2016
Country Of Origin
Brazil
Mentor Name
Yasmine Belkaid, Ph.D.

Research

Short-term infections can sometimes trigger chronic disorders, such as Crohn’s disease and even diabetes. When the body is under microbial attack, immune cells rush to the infected tissue and mount an attack on the invader. But the aftermath of this molecular and cellular immune response can linger long after the pathogen has been eliminated. Mice that are orally infected with a microbe retain activated immune cells in their abdomen, build up fat in their body, and show elevated levels of cholesterol even after the infection has been cleared. In the Belkaid lab, I will assess whether short-term infection alters the metabolism of activated immune cells and how they interact with other microorganisms at a later time by using sophisticated molecular and cellular technologies. Further, I will investigate whether these metabolically reprogrammed immune cells can initiate chronic, long-standing inflammation. The work could lead to novel treatments for chronic conditions such as Crohn’s disease, metabolic syndrome, or diabetes.