Leonardo K. Teixeira, Ph.D.

Title
Visiting Scientist
Department
Program of Cell Biology
Institution
Brazilian National Cancer Institute (INCA)
Address
R. Andre Cavalcanti, 37 - 5 andar
City, Zip
Rio de Janeiro, RJ, 20231-050
Country
Brazil
Phone
(55)(21) 3207-6701
E-mail
lkteixeira[at]inca.gov.br
Website
http://www.inca.gov.br/
Research Field
Cell biology
Award Year
2007
Country Of Origin
Brazil
Mentor Name
Steven I. Reed, Ph.D.

Research

Precise duplication of the genetic material and equal distribution to daughter cells are essential for maintaining genome integrity. Progression through the cell cycle is tightly regulated by a family of cyclin-dependent kinases (Cdk), which associate with respective cyclin subunits. In normal cells, cyclin E accumulates at the G1/S transition, and promotes DNA duplication by binding to and activating Cdk2. However, in different human cancers, cyclin E is frequently found to be overexpressed or deregulated, and is associated with tumor development and aggressiveness. Using a combination of cellular, molecular, biochemical, and genomic approaches, we are studying the mechanisms by which cyclin E/Cdk2 activity controls proper DNA replication in normal cells, and how deregulation of cyclin E perturbs S phase progression and leads to genomic instability in cancer.