- Postdoctoral Fellow
- National Institute of Neurological Disorders and Stroke, NIH
Porter Neuroscience Research Center
35 Convent Drive, Building 35A, Room 2C-911
- City, State, ZIP
- Bethesda, MD 20892-3704
- [email protected]
- Research field
- Cell Biology; Immunology
- Award year
- Country of origin
- Mentor name
- Richard J. Youle, Ph.D.
Mitochondria are dynamic intracellular organelles that, in addition to being crucial for energy production, are key players during innate immune responses. Recently, the Youle lab found that in people with early-onset Parkinson’s disease, the loss of proteins responsible for eliminating damaged mitochondria can precipitate inflammation. Therefore, my research at the Youle lab will focus on the molecular mechanisms underlying the relationship between mitochondria and the innate immune response. Using molecular genetics, high-resolution microscopy, immunology, and cell biology techniques, I will explore how proteins involved in mitochondrial quality control regulate STING, a protein that detects cyclic dinucleotides produced either by invading bacteria or by the cell itself in response to free cytosolic DNA. I will assess whether inactivating these proteins in human cell lines promotes STING hyperactivation and triggers inflammation—work that could lead to new strategies for alleviating aberrant immune responses in people with Parkinson’s disease or other neurodegenerative disorders.
2020 Search Pew Fellows
- Juan Carlos Balandrán, Ph.D.
- Gabriel Lozano Betancourt, Ph.D.
- Miguel Villavicencio Camarillo, Ph.D.
- Jeffrey Roberto Reina Garciasalas, Ph.D.
- Eunice Domínguez Martín, Ph.D.
- Fabián Morales Polanco, Ph.D.
- Luisa Maria Nieto Ramirez, Ph.D.
- Luciana Pádua Tavares, Ph.D.
- Gustavo Vasen, Ph.D.
- Estefanía Sánchez Vásquez, Ph.D.