Lee A. Niswander, Ph.D.


Our research focuses on the genetic and cellular mechanisms that control embryonic development. In particular we are interested in the processes required for closure of the neural tube and for development of the vertebrate limb and lung. Our approaches include a forward genetic screen in mice to identify mutations that affect specific processes of embryonic development and embryological and molecular manipulation of the chick embryo. A forward genetic approach is ideal for identifying key genes that regulate specific developmental processes of interest. In an on-going screen in mice for ENU (ethylnitrosourea)-generated mutations, we are identifying recessive mutations that disrupt specific aspects of embryonic development. We have focused on mutations that affect neural tube closure, limb and lung development.

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