Addressing the Scientific Hurdles Facing Antibiotic Innovation

Addressing the Scientific Hurdles Facing Antibiotic Innovation

Despite significant investment in drug discovery programs, research avenues pursued by industry and academia over the past three decades have largely failed to produce novel antibiotic agents because of knowledge gaps in basic science. For example, infections caused by Gram-negative bacilli present a pressing unmet need, as the cell structure of Gram-negative bacteria renders the pathogens particularly resistant to antibiotics.

As major pharmaceutical companies have downsized or abandoned antibiotic research and development, the task of addressing scientific obstacles has fallen to small companies and academic laboratories, whose resources may be limited. To rejuvenate antibiotic discovery, a growing number of experts agree that action is needed to address key scientific bottlenecks and to facilitate better collaboration across the private and public sectors. 

antibiotics label
antibiotics label
Press Releases & Statements

Pew Comments for 21st Century Cures Initiative

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Press Releases & Statements
Kids and Antibiotics
Kids Antibiotics
Data Visualization

Antibiotics Currently in Global Clinical Development

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Data Visualization

As of September 2017, an estimated 48 new antibiotics with the potential to treat serious bacterial infections are in clinical development. The success rate for clinical drug development is low; historical data show that, generally, only 1 in 5 infectious disease products that enter human testing (phase 1 clinical trials) will be approved for patients.

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