Anders Sejr Hansen, Ph.D.

Title
Assistant Professor
Department
Biological Engineering
Institution
Massachusetts Institute of Technology
Address
32 Vassar St., Building 56
Room 787B
City, state, ZIP
Cambridge, MA 02139
Phone
617-949-1835
Email
[email protected]
Website
https://www.ashansenlab.com/
Research field
Gene Regulation
Award year
2021

Research

The Hansen lab will investigate how genetic elements, known as enhancers, control the expression of genes in cancer. Notably, enhancers can be quite far away from the genes they control. The enhancers that regulate c-Myc, a gene commonly expressed in high levels in cancer, are amplified in lung and endometrial cancers. However, it is not well understood how having more copies of the enhancer actually drives the uptick in c-Myc expression. Using a combination of single-molecule and super-resolution live-cell imaging methods along with gene-editing tools, our lab will examine how long-range DNA loops are formed to promote functional interactions between enhancers and their target genes, and how that drives gene expression. This work will provide visual and real-time confirmation on how enhancers communicate with far away genes, and ultimately identify new therapeutic approaches to treat cancers driven by the overexpression of c-Myc.

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