Simone Engelender, M.D., Ph.D.
![Simone Engelender](/-/media/legacy/legacy-and-pre-launch-image-edits/scholars/1996/simone-engelender.jpg?la=en&h=138&w=130&hash=EA2E4ADF656CF2C27169D6682E7CC59B)
- Title
- Associate Professor
- Department
- Department of Molecular Pharmacology
- Institution
- Technion-Israel Institute of Technology
- Address
- POB 9649, Bat Galim
- City
- Haifa
- Country
- Israel
- [email protected]
- Website
- http://md.technion.ac.il/lecturers/lecturer_desc.asp?lecturerID=85&departmentID=6&contentCatID=4
- Research field
- Neuroscience
- Award year
- 1996
- Country of origin
- Brazil
- Mentor name
- Christopher A. Ross, M.D., Ph.D.
Research
We study the molecular mechanisms involved in Parkinson’s disease. We investigate how proteins involved in the disease, in special _-synuclein and synphilin-1 isoforms, form Lewy body-like inclusions. We also investigate how their ubiquitylation contributes to the formation of inclusions. We propose that ubiquitylation of synphilin-1 and _-synuclein represents a primary event for the formation of Lewy bodies and to pathogenesis of the disease.