Ethan Lee, M.D., Ph.D.

- Title
- Associate Professor
- Department
- Department of Cell and Developmental Biology
- Institution
- Vanderbilt University
- Address
-
465 21st Avenue South
U-4213A Learned Lab/MRBIII - City, State, ZIP
- Nashville, TN 37232-8240
- Phone
- (615) 322-1307
- [email protected]
- Website
- http://www.vanderbilt.edu/leelab/
- Research field
- Molecular Biology
- Award year
- 2004
Research
The Wnt pathway is an evolutionarily conserved signaling pathway present in all metazoans. During development, Wnt signaling coordinate the formation of tissues, organs, and limbs, and its misregulation leads to a variety of human disease states such Alzheimer's disease and cancer. My laboratory is interested in understanding the basic mechanism by which a Wnt signal is propagated and how this information can be used in regenerative medicine and in the treatment of cancer. A major experimental approach in my laboratory involves the use of Xenopus extracts and purified proteins to biochemically reconstitute Wnt signaling in vitro. Genome-scale screens, cultured mammalian cells, Xenopus embryos, Drosophila genetics (in collaboration with Dr. Laura Lee), and mouse studies are employed to compliment and extend our biochemical findings.
Scholar Keywords
2004 Search Pew Scholars
- Mark S. Anderson, M.D., Ph.D.
- James J. Chou, Ph.D.
- Valentin Dragoi, Ph.D.
- Michael A. Dyer, Ph.D.
- Nicole King, Ph.D.
- Ethan Lee, M.D., Ph.D.
- Guillermo Marqués, Ph.D.
- Tirin Moore, Ph.D.
- Valerie Reinke, Ph.D.
- JoAnn M. Sekiguchi, Ph.D.
- Lisa T. Stowers, Ph.D.
- Brian D. Strahl, Ph.D.
- Raphael H. Valdivia, Ph.D.
- Victor E. Velculescu, M.D., Ph.D.
- Ning Zheng, Ph.D.