Mara Sherman, Ph.D.

Mara
Title
Assistant Professor
Department
Cell, Developmental, and Cancer Biology
Institution
Oregon Health and Science University
Address
2730 S Moody Ave. CL6C
City, State, Zip
Portland, OR 97201
Phone
503-346-9012
E-mail
[email protected]
Website
https://www.ohsu.edu/school-of-medicine/sherman-lab
Research Field
Cancer Biology
Award Year
2020

Research

The Sherman lab will investigate the role of stroma—­the supportive tissue surrounding a tumor—in the evolution of pancreatic ductal adenocarcinoma (PDAC). PDAC is a unique cancer in which 50% to 90% of the tumor volume is occupied by dense stroma, the development of which is driven by cancer-associated fibroblasts. Recent research suggests that pancreatic stellate cells (PSCs) are the originators of these cancer-associated fibroblasts important for driving tumor progression. We will use a novel mouse model to track how PSCs may give rise to cancer-associated fibroblasts and determine how they subsequently contribute to the progression of PDAC. These efforts will shed light on the importance of the stroma in PDAC and the potential for stroma-based therapeutic development.

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