Esteban Orellana Vinueza, Ph.D.
- Title
- Assistant Professor
- Department
- Molecular and Systems Biology
- Institution
- Geisel School of Medicine at Dartmouth
- Address
-
66 College St
Remsen 725 - City, State, ZIP
- Hanover, NH 03755
- Phone
- 603-646-5962
- [email protected]
- Website
- https://orellanalab.org
- Research field
- Molecular biology, biochemistry
- Award year
- 2019
- Country of origin
- Ecuador
- Mentor name
- Richard I. Gregory, Ph.D.
The Orellana Lab studies the causes and effects of transfer RNA (tRNA) dysregulation in human disease and uses this knowledge to develop diagnostics and tRNA-based therapeutics. For many years, the contribution of tRNAs to human disease has been overlooked. Accumulating evidence indicates that the dynamic nature of tRNA modifications and the composition of the tRNA pool can contribute to human diseases, including cancer. The primary focus is to understand tRNA biology using cell culture and mouse models. The Orellana Lab employs bioinformatic, genetic, molecular, biochemical, and cell biological approaches to probe how perturbation of tRNAs results in disease.