We study gene circuits of relevance to human cancer including the p53 tumor suppressor network, the oncogenic serum response network and the hypoxia response network. We use a multidisciplinary approach combining anything from biochemical assays to genetic screens in human cells. Example projects are: 1) Investigating the role of diverse transcriptional co-factors in cell type-, stimulus- and promoter-specific regulation within these transcriptional programs. 2) employing genetic screens to identify new regulators of the cellular response to p53 activation and the hypoxic response. 3) Functional proteomic analysis of the mitochondrial apoptotic pathway.