Our interests lie at the interface of prokaryotic and eukaryotic biology during bacterial infections. In particular, we study the notorious human pathogen Mycobacterium tuberculosis, which is remarkably adept at subverting host immune cell function. We use genetics as a primary tool to identify bacterial genes required for pathogenesis, as well as employ a wide variety of complementary approaches to understand how the bacterium interacts with and alters its immune-cell niche, the macrophage.