Daniel E. Gottschling, Ph.D.

Sections

Daniel E. Gottschling, Ph.D.
Daniel Gottschling
Title
Member
Department
Division of Basic Sciences
Institution
Fred Hutchinson Cancer Research Center
Address
1100 Fairview Avenue N
Mailstop A3-025
City, State, ZIP
Seattle, WA 98109-1024
Phone
(206) 667-4494
Email
[email protected]
Website
http://research.fhcrc.org/gottschling/en.html
Research field
Genetics
Award year
1991

Research

Our laboratory uses the budding yeast Saccharomyces cerevisiae as a model system to investigate fundamental questions in biology. One of our current areas of interest is understanding the striking link between increasing age and the incidence of cancer in humans. A hallmark of cancer, genomic instability, is observed in all types of organisms including yeast. We recently discovered that as yeast cells enter the middle-to-late period of their replicative lifespan, they switch to a state of high genomic instability that persists until death. We believe this change represents a fundamental transition in many aging cells and thus are taking a number of approaches to understand the mechanism underlying this phenomenon.

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