The laboratory of Dr. Zhang studies structural and functional relations of macromolecules, which play crucial roles in variety of biological processes. The following are several areas that we are currently focusing on: 1) Structural and functional characterization of JmjC containing histone demethylases 2) Characterization of Novel signal transduction mechanism through TALL-1 and its cognate receptors 3) Structural and functional analysis of new transcription family members.