The Shared Platform for Antibiotic Research and Knowledge (SPARK)

Publicly available, interactive tool will provide data to help scientists around the world identify urgently needed new antibiotics

The Shared Platform for Antibiotic Research and Knowledge (SPARK)

One of the barriers to discovering new antibiotics is a lack of information sharing. Despite a long history of antibiotic research, scientists often cannot build on past work, or avoid repeating mistakes, because research findings are scattered across the academic literature or not publicly available. The field has also experienced a significant brain drain, losing years of experience as industry research-and-development teams have downsized or shifted to other therapeutic areas. And to make matters worse, the science itself—finding molecules that can break through the defenses of the toughest bacteria—is very difficult. 

To help address these challenges, Pew created the Shared Platform for Antibiotic Research and Knowledge (SPARK), a cloud-based, virtual laboratory that enables scientists to share data and insights, learn from past research, and generate new insights into how molecules enter and stay inside of Gram-negative bacteria. Using technology developed by Collaborative Drug Discovery, Inc., SPARK integrates chemical and biological data from published studies as well as previously unpublished data, and provides an opportunity for real-time collaboration among scientists in industry, academia, government, and the nonprofit sector.

Similar data-sharing tools have successfully catalyzed drug discovery in other research areas, such as cancer, neglected tropical diseases, and tuberculosis. Pew hopes that SPARK will do the same for antibiotic-resistant bacteria.

Register for access to SPARK

Note: Data provided to SPARK is managed by The Pew Charitable Trusts, an independent nonprofit organization. The intent is for all data shared with Pew to be made publicly available. If you have suggestions on data that should be included in SPARK, or are a researcher interested in donating your data to the platform, contact us at SPARK-data@pewtrusts.org.

Antibiotic resistance
Antibiotic resistance
Article

Information-Sharing Platform to Fill Knowledge Gaps Impeding Antibiotic Innovation

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The Shared Platform for Antibiotic Research and Knowledge is a groundbreaking and dynamic information-sharing platform. It will bring together curated antibiotic discovery data and cutting-edge analytics to help scientists tackle the scientific barriers blocking antibiotics discovery. While the global threat of antibiotic resistance continues to rise, nearly every antibiotic in use today is based on a discovery from more than 30 years ago. SPARK will focus on the unique challenges of finding and designing antibiotics that can defeat drug-resistant Gram-negative bacteria, which are among the hardest-to-treat superbugs.

SPARK Ecoli
SPARK Ecoli
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Meet the SPARK Experts

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Meet the SPARK Experts

A team of antibiotic discovery experts from around the world has collaborated with The Pew Charitable Trusts to help build its Shared Platform for Antibiotic Research and Knowledge (SPARK), which uses technology developed by Collaborative Drug Discovery, Inc.

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The Data Driving SPARK

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The Data Driving SPARK

To maximize the potential benefits of its Shared Platform for Antibiotic Research and Knowledge (SPARK), The Pew Charitable Trusts is working with a team of antibiotic discovery experts to ensure that the uploaded data are relevant, standardized, and of the highest quality.

OUR WORK

SPARK
SPARK

How to Request Access to the Shared Platform for Antibiotic Research and Knowledge (SPARK)

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How to Request Access to the Shared Platform for Antibiotic Research and Knowledge (SPARK)

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