Philip Kranzusch, Ph.D.

Pew.Feature.Scholar.Bio.Title
Assistant Professor
Pew.Feature.Scholar.Bio.Department
Cancer Immunology and Virology; Microbiology
Pew.Feature.Scholar.Bio.Institution
Dana-Farber Cancer Institute, Harvard Medical School
Pew.Feature.Scholar.Bio.Address
450 Brookline Ave.
Smith Building 756
Pew.Feature.Scholar.Bio.City, Pew.Feature.Scholar.Bio.State, Pew.Feature.Scholar.Bio.Zip
Boston, MA 02215
Pew.Feature.Scholar.Bio.Phone
617-582-9322
Pew.Feature.Scholar.Bio.Email
[email protected]
Pew.Feature.Scholar.Bio.Website
http://kranzuschlab.med.harvard.edu
Pew.Feature.Scholar.Bio.ResearchField
Molecular Biology; Biochemistry
Pew.Feature.Scholar.Bio.AwardYear
2019

Research

The Kranzusch lab will investigate how small RNA molecules can activate an immune response to pathogens or cancer. Cells rely on a variety of signaling molecules that direct their response to changing environmental conditions, developmental cues, or signs of infection or disease. As a postdoctoral fellow, I studied a recently identified enzyme named cGAS that generates an RNA signal to broadcast an “alarm” when a cell detects mislocalized DNA or pathogen replication. My lab discovered that cGAS is part of a new family of signaling proteins that includes more than 5,000 enzymes in bacteria and several human proteins of unknown function. Now, using biochemistry, structural biology, and cellular techniques, our group will identify the RNA signals synthesized by these proteins and determine their roles in human immunity and host-pathogen interactions. Our research will explain how cGAS-like enzymes shape the cellular immune response—work that could lead to novel ways of eliminating infections or cancer.

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