Andrew Wang, M.D., Ph.D.
![](/-/media/post-launch-images/2020/06/biomed/andrew-wang.jpeg?la=pt&h=479&w=479&hash=6B01F4B41BDF2A0B5E72EFE520BA3117)
- Title
- Assistant Professor
- Department
- Internal Medicine; Immunobiology
- Institution
- Yale University
- Address
-
300 Cedar St.
P.O. Box 208031 - City, State, ZIP
- New Haven, CT 06510
- Phone
- 203-785-2454
- [email protected]
- Website
- https://medicine.yale.edu/profile/andrew_wang/
- Research field
- Immunology; Metabolism; Physiology
- Award year
- 2020
Research
The Wang lab will explore how different environmental factors affect the trajectory of inflammatory diseases. When laboratory animals that are genetically identical and live in the same cages are exposed to an inflammatory challenge, such as a toxin, allergen, or infection, some will recover while others die. These dramatically different outcomes likely relate to slight differences in each animal’s personal “environment”—when it last ate, how well it slept, or whether it was experiencing some psychological or physical stress. In preliminary studies, I determined how the stress produced by physical restraint or social isolation altered how an animal responded to inflammatory challenges. Now, my lab will establish how environmental factors such as fasting, diet, and stress influence how animals handle different types of inflammation, including bacterial and viral infections and allergic challenges, and we will identify the molecules that boost their chances of survival. Working with clinical samples, we will assess if these same molecules correlate with how patients manage inflammation, work that could provide new ways to manage or prevent life-threatening inflammatory conditions such as sepsis and anaphylaxis.
Scholar Keywords
2020 Search Pew Scholars
- Michael Baym, Ph.D.
- Bérénice Benayoun, Ph.D.
- Shelby Blythe, Ph.D.
- Xiaolu (Lulu) Cambronne, Ph.D.
- Carlos Carmona-Fontaine, Ph.D.
- Juan Du, Ph.D.
- Daria Esterhazy, Ph.D.
- Gilad Evrony, M.D., Ph.D.
- Sarah Keane, Ph.D.
- Meghan Koch, Ph.D.
- Evan Macosko, M.D., Ph.D.
- Sonya Neal, Ph.D.
- Lauren O’Connell, Ph.D.
- Lauren Orefice, Ph.D.
- Eunyong Park, Ph.D.
- Benjamin Parker, Ph.D.
- Seth Shipman, Ph.D.
- Nicholas Steinmetz, Ph.D.
- Samuel Sternberg, Ph.D.
- Christoph Thaiss, Ph.D.
- Andrew Wang, M.D., Ph.D.
- Jeffrey Woodruff, Ph.D.