Tomás L. Falzone

Research

The focus of my lab research is to understand the role of motor proteins in axonal transport and to comprehend how impairments in transport may derive in the manifestation of neurodegenerative diseases such as Alzheimer’s disease. Using fluorescent-tagged cargos we want to understand the axonal transport properties of proteins, vesicles and organelles. This tracking technique used in combination with biochemistry and pathological characterization of motor protein mutant mice are currently used to identify the role of motor proteins in the initiation and progression of pathologies that may arise upon transport defects. The future goal of the laboratory is to generate a neuronal model from human stem cell differentiation to study axonal transport properties in normal conditions and disease.