Saskia B. Neher, Ph.D.

Pew.Feature.Scholar.Bio.Title
Assistant Professor
Pew.Feature.Scholar.Bio.Department
Department of Biochemistry and Biophysics
Pew.Feature.Scholar.Bio.Institution
University of North Carolina at Chapel Hill
Pew.Feature.Scholar.Bio.Address
120 Mason Farm Rd.
CB 7260
Pew.Feature.Scholar.Bio.City, Pew.Feature.Scholar.Bio.State, Pew.Feature.Scholar.Bio.Zip
Chapel Hill, NC 27599
Pew.Feature.Scholar.Bio.Phone
(919) 966-9550
Pew.Feature.Scholar.Bio.Email
[email protected]
Pew.Feature.Scholar.Bio.Website
http://neherlab.web.unc.edu/
Pew.Feature.Scholar.Bio.ResearchField
Biochemistry
Pew.Feature.Scholar.Bio.AwardYear
2012

Research

Research in my lab focuses on understanding the molecular mechanisms responsible for regulation of lipase activity. We aim to uncover how a transmembrane maturation factor assists in proper folding and ER exit of a group of dimeric mammalian lipases. We also study secreted proteins that regulate lipase activity in response to changes in nutritional state. Our research has biomedical relevance because biochemical deficiencies in lipase activity can cause hypertriglyceridemia, which is associated with increased risk for atherosclerosis. Our approach is interdisciplinary and uses membrane protein biochemistry, enzymology, and structural biology to understand lipase structure-function relationships.

Pew.Feature.Scholar.Search.SearchTitle